2/19/2023 0 Comments Christina haak autoimmune issues![]() (3,4) According to the latest data, as of April 20, 2021, the virus has affected more than 140 million people, and deaths have surpassed more than 3 million. Subsequently, the virus rapidly spread worldwide with a high transmission efficacy. (1,2) SARS-CoV-2 first appeared in previously unexposed human populations in late 2019 in Wuhan, China, from an undisclosed source. The coronavirus disease-19 (COVID-19) pandemic is a potentially fatal respiratory infection caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we highlight kinases that are associated with coronavirus infections and their inhibitors with antiviral and potentially anti-inflammatory, cytokine-suppressive, or antifibrotic activity. ![]() ![]() Some kinases play a significant role throughout the viral infection cycle (entry, replication, assembly, and egress), and several of them are involved in the virus-induced hyperinflammatory response that leads to cytokine storm, acute respiratory distress syndrome (ARDS), organ injury, and death. Viral infections hijack abundant cell signaling pathways, resulting in drastic phosphorylation rewiring in the host and viral proteins. Several kinases have been proposed as possible mediators of multiple viral infections, including life-threatening coronaviruses like SARS-CoV-1, Middle East syndrome coronavirus (MERS-CoV), and SARS-CoV-2. The novel human severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been identified as an etiological agent for COVID-19. The global coronavirus disease-19 (COVID-19) has affected more than 140 million and killed more than 3 million people worldwide as of April 20, 2021.
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